Spruce Mill Brook is a major tributary to the Boquet River and features stocked brook and brown trout. The brook begins as a series of small feeder streams in the town of Lewis and joins the North Branch of the Boquet River just south of Reber.

Anglers may find some native brook trout in the upper reaches; stocking usually begins closer to the actual town of Lewis. Access is good just upstream from the North Branch; another access spot is located where the brook crosses 1-87. Try west of I-87 (Adirondack Northway), off Dixon Road or County Highway 12.